The phrase you and I acts as the subject in a sentence. As a general rule, write you and I if the pronoun we can be used instead.
- You and I (we) should go see the scarlet carpet that lines the path to the Miscou Island Lighthouse.
- You and I (we) need to sort this out.
- I told Lisa that you and I (we) baked her birthday cake.
The phrase you and me acts as an object, most often as the indirect object of a verb or as the object of a preposition (e.g. about, after, at, between, for, from and to). Choose you and me if the pronoun us can be used instead.
- Jacques saw you and me (us) at the mall yesterday.
- Did Shawna intentionally throw the ball at you and me (us)?
- Just between you and me (us), I think we should leave now.
- The gifts were intended for you and me (us).
- Dylan has not written to you and me (us) since he left town.
- Everyone but you and me (us) was invited to the barbecue.
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