The combining form mal- has four meanings.
Meaning 1: bad, badly
- A malodorous discharge may indicate an infection.
Meaning 2: abnormal, abnormally
- The child was born with a heart malformation.
Meaning 3: poor, poorly
- The organization works to save the lives of malnourished children.
Meaning 4: not
- The young man was very maladroit.
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